Don't try to fit too much onto one page when you're designing a website. If your page is too busy it will take a lot longer to load and can overwhelm visitors. When you're going to be putting up a lot of content, create pages for everything you can to reduce the clutter on your page.
Don't use splash pages for your site unless required by law, and especially don't use a Flash intro. Most people just want to get to your content as quickly as possible, and don't care to look at useless splash pages. If you have some amusing content that you absolutely want visitors to see, integrate it into the homepage instead.
Include a link to the homepage on every page of your site. One of the best ways to do this is to make a graphic title for your page that can be included on all pages. Web users are used to clicking on a graphic to return home so there won't be a learning curve to navigating your site.
Make sure all of your webpages actually have titles, and make sure they are descriptive. A surprising number of webpages out there are called "untitled document" or "new document". This not only denies visitors a useful piece of information to remember your site, but also absolutely destroys your SEO, since search engines weight page titles heavily when ranking sites.
Don't disable the visitor's right-click functionality. Some sites do this in order to prevent people from copying and pasting text or saving images from the site. The thing is, it doesn't work and disables other useful functions. OCR can be used to capture text from such sites, and grabbing images is as simple as taking a screenshot.
Keep the sizes of your files and images small. Excessive loading times are a death knell for any site. The larger the files are that must load, the longer a user's load time is going to be. Most users will click away if the page doesn't start to load within the first few seconds of opening your page.
Make sure your website uses a consistent font throughout. Some websites change fonts willy-nilly without any design reason to do so. This makes the content difficult to process for visitors. Most websites, especially business websites, will do just fine sticking to basic fonts like Arial, Veranda, or even Times New Roman.
As stated before, just about everyone, including you, has wanted to create a website. People have had ideas on what their website will be like for years, but become stuck in the actual creation process. This hurdle can be easily jumped from using the web design tips mentioned in the article above.